Today, many producers of biological products are moving towards the use of disposable equipment and devices. In previous methods, the production of recombinant proteins by bacteria, yeasts and animal cells in commercial quantities was done by expensive equipment that was washed and sterilized many times. In order to produce in accordance with GMP principles, it is necessary to comply with certain requirements in order to prevent cross-contamination. In all stages, many instructions are compiled to perform the work, to ensure the correctness of the operations and to control the work steps, which increases the work costs, personnel training and spends a lot of time. The main concern of working with fermentor is the problem of contamination with non-target microorganisms and also cross-contamination. Even though measures have been taken to prevent the occurrence of pollution, which is often difficult and sometimes even with all care, pollution still causes a waste of capital.
In the new generation bioreactors, there is no need for washing and sterilization, and even the sensors are provided as disposable. This technology reduces the downtime of the equipment between two batches, because only the cultivation bag will be replaced. While in steel stirred reactors, the interval between two batches is 8 to 10 hours, and in case of changing the production line to another product, it takes up to 3 weeks. In short, it can be said that in Single-Use bioreactor technology, there is no need to prepare the device for the process, and to start the new process, only the culture medium is added in a pre-sterile bag and then it is placed on the device. This process reduces the preparation time, eliminates the steps of washing and sterilization and validates them, the possibility of performing several processes at the same time, etc.
In the production of small volume products such as glycoproteins and vaccines, all process steps can be done in these bioreactors. Beta interferon and therapeutic and diagnostic monoclonal antibodies are among the most important domestic products that can be used in their production.
Proliferation and differentiation of stem cells
Cultivation of animal, plant and virus cells
Preparation of inoculum for higher volume bioreactors
Quick preparation of the product needed to perform clinical tests
Cultivation of yeast cells and bacteria at the limit of low and medium concentration cultures
Production of recombinant proteins, monoclonal antibodies and vaccines according to the GMP standard
Increasing production volume from low volume flasks and culture flasks
This device includes a one-year warranty and 10 years of after-sales service.
By providing the highest level of after-sales service for our customers, we have been able to meet their needs in the shortest possible time, and without a doubt, providing this is only technically possible with the support of an experienced and experienced staff.
It is used to inject and transfer fluids at a desired speed. Pardis Sina Process Company has four models of peristaltic pumps with the ability to move liquids from 0.1 to 10000 ml/min with excellent quality and very easy to use. The important point is that for a choice that suits the needs of laboratory fluids and industrial fluids, the importance of fluid transfer, the range of viscosity, the intensity of fluid transfer and the size of the displaced fluid should be considered.
In the cell culture process, the accuracy and stability of the CO2 incubator is very important. During this process, the smallest change in CO2 atmosphere, temperature and humidity can affect the cell culture. In addition, culture medium and cells have economic value and sometimes cultures cannot be repeated and therefore they need stable and reliable culture conditions, which is achieved by Sina CO2 incubators. Sina incubators have optical CO2 sensors that have high accuracy and detection speed and are very suitable for sensitive cell cultures. Also, due to easy operation and no need for continuous maintenance, the user’s time and side costs are saved.
در فرآیند کشت سلول دقت و ثبات عملکرد انکوباتور CO2 بسیار حائز اهمیت می باشد. در طی این فرآیند کمترین تغییر در اتمسفر CO2، دما و رطوبت می تواند کشت سلول ها را تحت تاثیر قرار دهد. علاوه بر این محیط کشت و سلول ها دارای ارزش اقتصادی بوده و گاهی اوقات کشت ها قابل تکرار نیستند و به همین دلیل نیازمند شرایط کشت پایدار و قابل اطمینان هستند که این امر توسط انکوباتورهای CO2 سینا محقق می گردد. انکوباتورهای سینا دارای سنسورهای CO2 از نوع اپتیکال می باشد که دقت و سرعت تشخیص بالایی داشته و جهت کشت های سلولی حساس بسیار مناسب می باشد. همچنین به دلیل عملکرد آسان و عدم نیاز به نگهداری مداوم، در زمان و هزینه های جانبی کاربر صرفه جویی می گردد.